Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.

@article{WyssCoray1995IncreasedCN,
  title={Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.},
  author={Tony Wyss-Coray and Lijun Feng and Eliezer Masliah and Mary D. Ruppe and Hang Shela Lee and Stephanie M. Toggas and Edward M. Rockenstein and Lennart Mucke},
  journal={The American journal of pathology},
  year={1995},
  volume={147 1},
  pages={
          53-67
        }
}
A number of important neurological diseases, including HIV-1 encephalitis, Alzheimer's disease, and brain trauma, are associated with increased cerebral expression of the multifunctional cytokine transforming growth factor-beta 1 (TGF-beta 1). To determine whether overexpression of TGF-beta 1 within the central nervous system (CNS) can contribute to the development of neuropathological alterations, a bioactive form of TGF-beta 1 was expressed in astrocytes of transgenic mice. Transgenic mice… CONTINUE READING

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