Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers.

@article{Politis2015IncreasedCM,
  title={Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers.},
  author={Marios Politis and Nayana Lahiri and Flavia Niccolini and Paul J. Su and Kit Wu and Paolo Giannetti and Rachael I. Scahill and Federico E. Turkheimer and Sarah J Tabrizi and Paola P Piccini},
  journal={Neurobiology of disease},
  year={2015},
  volume={83},
  pages={115-21}
}
Previous studies have shown activation of the immune system and altered immune response in Huntington's disease (HD) gene carriers. Here, we hypothesized that peripheral and central immune responses could be concurrent pathophysiological events and represent a global innate immune response to the toxic effects of mutant huntingtin in HD gene carriers. We… CONTINUE READING