Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta.

@article{Gebken2000IncreasedCS,
  title={Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta.},
  author={J. Gebken and Rolf Brenner and A Feydt and Holger Notbohm and Juergen Brinckmann and Peter K. M{\"u}ller and Boris B{\"a}tge},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={2000},
  volume={68 3},
  pages={106-12}
}
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder usually characterized by either a reduction in the production of normal collagen I or the synthesis of abnormal collagen. The variability in the clinical phenotype is not in each case sufficiently explained by the underlying mutation in the collagen I genes. Also, biochemical differences between mutant collagen from different tissues suggest additional regulatory mechanisms possibly involved in matrix deposition and… CONTINUE READING