Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.

Abstract

The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a class of inhibitors known as the… (More)

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Cite this paper

@article{Colella2002IncreasedCD, title={Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.}, author={Rita Colella and Erik Goodwyn and Purva Gopal}, journal={Cancer letters}, year={2002}, volume={185 2}, pages={163-72} }