Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor.

@article{Chomez2000IncreasedCD,
  title={Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor.},
  author={P Chomez and I Neveu and A. J. Mansen and Eva Kiesler and L Larsson and Bj{\"o}rn Vennstr{\"o}m and E Arenas},
  journal={Development},
  year={2000},
  volume={127 7},
  pages={1489-98}
}
  • P Chomez, I Neveu, +4 authors E Arenas
  • Published 2000 in Development
The rev-erbA(alpha) gene, belonging to the steroid receptor superfamily of transcription factors, is highly conserved during evolution but little is known so far about its functions in development or in adult physiology. Here, we describe genetically altered mice lacking the rev-erbA(alpha) gene. These animals do not show any obvious phenotype in either fat tissue or skeletal muscle, despite the known regulation of rev-erbA(alpha) expression during adipocyte and myotube differentiation in vitro… CONTINUE READING