Increased cell-associated IL-8 in human exudative and A23187-treated peripheral blood neutrophils.

@article{Kuhns1995IncreasedCI,
  title={Increased cell-associated IL-8 in human exudative and A23187-treated peripheral blood neutrophils.},
  author={Douglas B. Kuhns and John I. Gallin},
  journal={Journal of immunology},
  year={1995},
  volume={154 12},
  pages={6556-62}
}
IL-8 is a potent neutrophil chemoattractant that has been detected in high concentrations at acutely inflamed sites in vivo. Many cell types, including peripheral blood neutrophils, produce IL-8 that can be released by a variety of pro-inflammatory stimuli. However, the functional importance of neutrophil IL-8 during exudation is not yet known. We now report that neutrophils, harvested from skin lesions on the forearms of normal human volunteers (exudative neutrophils), expressed 100-fold… CONTINUE READING
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