Increased caveolin-1 expression in Alzheimer's disease brain.

  title={Increased caveolin-1 expression in Alzheimer's disease brain.},
  author={Sophie B Gaudreault and Doris Dea and Judes Poirier},
  journal={Neurobiology of aging},
  volume={25 6},
Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and aged-matched control subjects. Our results demonstrate that caveolin protein levels in the hippocampus and caveolin mRNA in the frontal cortex are up-regulated in AD by approximately… CONTINUE READING


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