Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells.

@article{Park2005IncreasedCA,
  title={Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells.},
  author={Jeong-Soo Park and Hee-Young Kim and Hyang-Won Kim and Gi-Nam Chae and Hyung-Tae Oh and Jinyoung Park and Hosup Shim and Min Seo and Eun-Young Shin and E Kim and Sang Chul Park and S I Kwak},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 5},
  pages={551-9}
}
Mesenchymal stem cell (MSC) has drawn much attention in the aspect of tissue renewal and wound healing because of its multipotency. We initially observed that bone marrow-derived human MSCs (hMSCs) divided poorly and took flat and enlarged morphology after expanded in culture over a certain number of cell passage, which resembled characteristic features of senescent cells, well-studied in human diploid fibroblasts (HDFs). More interestingly, adipogenic differentiation potential of hMSCs sharply… CONTINUE READING

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