Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats.

@article{Souza2008IncreasedCS,
  title={Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats.},
  author={Hugo Souza and Geisa C S V Terzini and Valdo Jos{\'e} Dias da Silva and Marli Cardoso Martins-Pinge and H{\'e}lio C{\'e}sar Salgado and Maria-Cristina O Salgado},
  journal={Clinical and experimental pharmacology & physiology},
  year={2008},
  volume={35 7},
  pages={
          751-6
        }
}
1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated group compared with the control group (418 +/- 5 vs 357 +/- 4 b.p.m., respectively; P < 0.001). This baseline tachycardia was associated with a lower baroreflex sensitivity of the… CONTINUE READING
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