Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B.

@article{Reisenauer2007IncreasedCP,
  title={Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B.},
  author={Anita Reisenauer and Oliver Eickelberg and Aline Wille and A. v. Heimburg and Annegret Reinhold and Bonnie F Sloane and Tobias Welte and Frank Buehling},
  journal={Biological chemistry},
  year={2007},
  volume={388 6},
  pages={639-50}
}
The TGF-beta signaling pathways are implicated in cancer. Cysteine cathepsins can contribute to the carcinogenic potential of tumor cells. The aim of this study was to investigate the regulation of cysteine cathepsin expression by TGF-beta1 and the functional implications in tumor cells. We found an upregulation of cathepsin B (CathB, 2- to 5-fold) in different myeloid tumor cells (THP-1, MonoMac-1, MonoMac-6) after incubation with TGF-beta1. No upregulation was found in monocytes, and there… CONTINUE READING

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