Increased carbon monoxide concentration in exhaled air after surgery and anesthesia.

  title={Increased carbon monoxide concentration in exhaled air after surgery and anesthesia.},
  author={Masao Hayashi and Toru Takahashi and Hiroshi Morimatsu and Hiromi Fujii and Naoyuki Taga and Satoshi Mizobuchi and Masaki Matsumi and Hiroshi Katayama and Masataka Yokoyama and Masahiro Taniguchi and Kiyoshi Morita},
  journal={Anesthesia and analgesia},
  volume={99 2},
  pages={444-8, table of contents}
Heme oxygenase-1 (HO-1) is induced by oxidative stress and is thought to confer protection against oxidative tissue injuries. HO-1 catalyzes the conversion of the heme moiety of hemeproteins, such as hemoglobin, myoglobin, and cytochrome P450, to biliverdin, liberating carbon monoxide (CO) in the process. CO reacts with hemoglobin to form carboxyhemoglobin. In this study, to examine the effect of anesthesia and/or surgery on endogenous CO production, we measured the amount of exhaled CO and the… CONTINUE READING


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