Increased capillary permeability mediated by a dengue virus-induced lymphokine.

@article{Khanna1990IncreasedCP,
  title={Increased capillary permeability mediated by a dengue virus-induced lymphokine.},
  author={Madhu Khanna and Umesh Chandra Chaturvedi and Mahesh Chand Sharma and V. C. Pandey and A. C. Mathur},
  journal={Immunology},
  year={1990},
  volume={69 3},
  pages={449-53}
}
The mechanism of increased capillary permeability, seen in cases of dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), is not known. Dengue type 2 virus (DV) is known to induce production of a lymphokine, the cytotoxic factor (CF), by the T lymphocytes of mouse spleen. The data presented here show that intraperitoneal inoculation of CF in mice results in increased capillary permeability in a dose-dependent manner, as shown by leakage of intravenously injected radiolabelled iodine… CONTINUE READING