Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

@article{Gross1983IncreasedCE,
  title={Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.},
  author={Janet L. Gross and David Moscatelli and Daniel B. Rifkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 9},
  pages={2623-7}
}
Bovine capillary endothelial (BCE) cells produce increased amounts of the proteases plasminogen activator (PA) and latent collagenase when cultured in the presence of the following preparations which are known to contain angiogenic activities: bovine retinal extract, mouse adipocyte conditioned medium, and human hepatoma cell lysate. These preparations stimulated both BCE cell PA and collagenase activities in a dose-dependent manner. Both activities were increased to about the same level by… CONTINUE READING