Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices.

@article{Rosenfeldt1998IncreasedCM,
  title={Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices.},
  author={Hans M Rosenfeldt and Dong Hoon Lee and Frederick Grinnell},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 5},
  pages={2659-67}
}
We studied early changes in gene expression during fibroblast contraction of stressed collagen matrices. The level of c-fos mRNA increased dramatically and peaked 50 to 60 min after matrix contraction was initiated. This response did not require serum and could not be accounted for simply by disruption of the actin cytoskeleton. Increased c-fos mRNA levels required Ca2+ influx but not the cyclic AMP or extracellular signal-regulated kinase (ERK 1/2) signaling pathways, both of which are… CONTINUE READING