Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene

@article{Gehricke2015IncreasedBA,
  title={Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene},
  author={J. Gehricke and J. Swanson and Sophie Duong and Jenny L Nguyen and T. Wigal and J. Fallon and Cyrus Caburian and L. Muftuler and R. Moyzis},
  journal={Psychiatry Research: Neuroimaging},
  year={2015},
  volume={231},
  pages={58-63}
}
The aim of the study was to examine functional brain activity in response to unpleasant images in individuals with the 7-repeat (7R) allele compared to individuals with the 4-repeat (4R) allele of the dopamine receptor D4 (DRD4) gene (VNTR in exon 3). Based on the response ready hypothesis, individuals with the DRD4-4R/7R genotype were expected to show greater functional brain activity in response to unpleasant compared to neutral stimuli in specific regions of the frontal, temporal, parietal… Expand

Paper Mentions

Observational Clinical Trial
The study investigated the underlying mechanisms of smoking in young adults by examining the associations between smoking, brain activity, dopamine genes, and attention deficit… Expand
ConditionsADHD, Smoking, Withdrawal Nicotine
InterventionBehavioral
Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD
TLDR
Polymorphisms of the DRD4 gene, specifically 2-repeat allele, had effects on the ECN, the SMN and the DMN, especially in the prefrontal cortex (PFC) circles. Expand
Predicted DRD4 prefrontal gene expression moderates snack intake and stress perception in response to the environment in adolescents
TLDR
Results are consistent with a differential susceptibility model in which genes influencing environmental responsiveness interact with environments varying in obesogenicity to confer behavioral obesity risk in a less favorable environment, but behavioral obesity protection in a favorable one. Expand
ADGRL3, FGF1 and DRD4: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD
TLDR
The potential presence of the linkage and association of single-nucleotide polymorphisms (SNPs) harbored in genes implicated in the etiology of ADHD, with cognitive endophenotypes related to working memory and perceptual organization in 113 nuclear families are explored. Expand
Association between the dopamine D4 receptor gene exon III variable number of tandem repeats and political attitudes in female Han Chinese
TLDR
The results provided evidence for a role of the DRD4 gene variants in contributing to individual differences in political attitude particularly in females and more generally suggested that associations between individual genes, and neurochemical pathways, contributing to traits relevant to the social sciences can be provisionally identified. Expand
Neurobehavioral foundation of environmental reactivity.
TLDR
A comprehensive neurobehavioral framework of environmental reactivity based on a combinatorial model of a supertrait based on an organizing threshold model of elicitation of neurobiology by environmental context is provided. Expand
Imaging genetics in attention-deficit/hyperactivity disorder and related neurodevelopmental domains: state of the art
TLDR
It is found that IG studies on ADHD generally focus on dopaminergic genes and the structure of basal ganglia using structural Magnetic Resonance Imaging (MRI). Expand
DRD4 Genotype and the Developmental Link of Peer Social Preference with Conduct Problems and Prosocial Behavior Across Ages 9–12 Years
TLDR
Investigating whether variations in the DRD4 gene moderated the association between children’s social standing in the peer group with subsequent conduct problems and prosocial behavior among 405 elementary school children found that children who had higher positive social preference scores showed less conduct problem development in subsequent years relative toChildren who had lower positive social preferences. Expand
Emotional insecurity as a mediator of the moderating role of dopamine genes in the association between interparental conflict and youth externalizing problems
TLDR
Mediated moderation findings indicated that adolescent reports of their emotional insecurity in the interparental relationship partially explained the greater genetic susceptibility experienced by these children. Expand
Dopamine DRD4 gene polymorphism as a risk factor for epilepsy in autism spectrum disorder
TLDR
The prevalence of the polymorphisms of the DRD4 gene, its effects on clinical characteristics of ASD, and its association with epilepsy in ASD patients were evaluated. Expand
A meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia
TLDR
Results of pooled analysis indicated that the −521 CC variant and genotype L/L (ie, long allele) of the 120 bp TR were risk factors of schizophrenia and the 48 bp VNTR, the 12bp TR, the −616 C>G polymorphism, and the −376 C>T polymorphism were not associated with schizophrenia. Expand
...
1
2
...

References

SHOWING 1-10 OF 62 REFERENCES
Regional brain responses to pleasant and unpleasant IAPS pictures: Different networks
TLDR
Although an overlap in regions involved in the processing of pleasant and unpleasant IAPS pictures exists, the neural network for each is unique. Expand
Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.
An association of the dopamine receptor D4 (DRD4) gene located on chromosome 11p15.5 and attention deficit/hyperactivity disorder (ADHD) has been demonstrated and replicated by multipleExpand
Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function
TLDR
The current results are consistent with animal studies that show a role for dopamine and specifically the DRD4 receptor in sexual behavior and suggest that one pathway by which individual variation in human desire, arousal and function are mediated is based on allelic variants coding for differences in DRD 4 receptor gene expression and protein concentrations in key brain areas. Expand
Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.
TLDR
In children with ADHD, possession of the DRD4 7-repeat allele appears to be associated with an inaccurate, impulsive response style on neuropsychological tasks that is not explained by ADHD symptom severity. Expand
Emotion comprehension in the temporal variant of frontotemporal dementia.
TLDR
The data indicate that tvFTD is associated with impairments in emotional processing that may underlie some behavioural problems in this disorder, and that the emergence of such deficits depends on the specific pattern of anatomical injury. Expand
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.
TLDR
It is estimated that the 7R allele arose prior to the upper Paleolithic era (approximately 40000-50000 years ago), and a model for selection at the DRD4 locus is proposed consistent with these observed LD patterns and with the known biochemical and physiological differences between receptor variants. Expand
Expecting unpleasant stimuli – An fMRI study
TLDR
Different regions of the anterior cingulate gyrus and the thalamus were solely active during expectation of the unpleasant stimuli, which may reflect a network for internal adaptation and preparation processes in order to react adequately to expected unpleasant events. Expand
Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study
TLDR
Evidence of a functional role of DRD4 VNTR genotype in the expression of craving for alcohol is interpreted as generally supporting Loewenstein's visceral theory of craving and evidence of an influence on reactivity to the craving induction. Expand
An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood
  • R. Barkley, K. Smith, M. Fischer, B. Navia
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2006
TLDR
The DAT1 40bp VNTR 9/10 polymorphism pairing appears to be reliably associated with greater symptoms of ADHD and externalizing behavior from childhood to adulthood, and with family, educational, and occupational impairments. Expand
Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity
  • E. Congdon, K. Lesch, T. Canli
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
Results of the present study support the influence of dopaminergic variation on impulsive‐related measures, as well as the advantage of using measures which are likely more sensitive to the effects of such genetic variation. Expand
...
1
2
3
4
5
...