Increased bone mass in mice lacking the adipokine apelin.

@article{Wattanachanya2013IncreasedBM,
  title={Increased bone mass in mice lacking the adipokine apelin.},
  author={Lalita Wattanachanya and Wei-Dar Lu and Ramendra K. Kundu and Liping Wang and Marcia J Abbott and Dylan O'Carroll and Thomas Quertermous and Robert A. Nissenson},
  journal={Endocrinology},
  year={2013},
  volume={154 6},
  pages={
          2069-80
        }
}
Adipose tissue plays an important role in skeletal homeostasis, and there is interest in identifying adipokines that influence bone mass. One such adipokine may be apelin, a ligand for the Gi-G protein-coupled receptor APJ, which has been reported to enhance mitogenesis and suppress apoptosis in MC3T3-E1 cells and primary human osteoblasts (OBs). However, it is unclear whether apelin plays a physiological role in regulating skeletal homeostasis in vivo. In this study, we compared the skeletal… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Negative Skeletal Effects of Locally Produced Adiponectin

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Novel pathogenesis: regulation of apoptosis by Apelin/APJ system.

  • Acta biochimica et biophysica Sinica
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND