Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.

@article{Kontoyiannis2007IncreasedBM,
  title={Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.},
  author={Dimitrios P Kontoyiannis and Georgios Chamilos and Russell E Lewis and Sergio Giralt and J. C. Gal{\'a}n Cort{\'e}s and Issam I. Raad and John T. Manning and Xin Han},
  journal={Cancer},
  year={2007},
  volume={110 6},
  pages={1303-6}
}
BACKGROUND Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence. METHODS In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those… CONTINUE READING