Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow.

@article{Nishida1994IncreasedBF,
  title={Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow.},
  author={Seikoh Nishida and Akira Yamaguchi and Tatsuhiko Tanizawa and Naoto Endo and Tasuku Mashiba and Yasuo Uchiyama and Tatsuo Suda and Shusaku Yoshiki and Hideaki Takahashi},
  journal={Bone},
  year={1994},
  volume={15 6},
  pages={717-23}
}
In order to examine the mechanism of the anabolic effect of parathyroid hormone (PTH) on bone formation, human PTH(1-34) [hPTH(1-34)] (30 micrograms/kg) was injected subcutaneously to 9-week-old rats 5 times a week for 1 or 3 weeks. Trabecular bone volume (BV/TV) in the tibial metaphysis was not significantly different between the PTH- and vehicle-treated groups, but the parameters related to bone formation, including osteoid surface (OS/BS), mineralizing surface (MS/BS), mineral apposition… CONTINUE READING

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