Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency.

@article{OHalloran1993IncreasedBD,
  title={Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency.},
  author={Domhnall J O'Halloran and Agathocles Tsatsoulis and Richard W. Whitehouse and Steven J. Holmes and Judith E. Adams and Stephen M. Shalet},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 5},
  pages={
          1344-8
        }
}
The physiological role of GH in the adult skeleton is unknown. In this study, 12 adults (10 males and 2 females) with isolated GH deficiency were treated with GH as a single daily sc injection (0.125 IU/kg.week for the first 4 weeks and subsequently at 0.25 IU/kg.week) for 1 yr in a double blind, placebo-controlled manner. Bone mineral density of the spine (T12-L3) was measured by quantitative computed tomography, and bone mineral content (BMC) of the forearm by single photon absorptiometry at… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 54% COVERAGE

Focus on growth hormone deficiency and bone in adults.

  • Best practice & research. Clinical endocrinology & metabolism
  • 2017

FILTER CITATIONS BY YEAR

1995
2018

CITATION STATISTICS

  • 2 Highly Influenced Citations