Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency

@article{Rosn1993IncreasedBF,
  title={Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency},
  author={T. Ros{\'e}n and I. Bosaeus and Jukka T{\"o}Ili and G. Lindstedt and B. Bengtsson},
  journal={Clinical Endocrinology},
  year={1993},
  volume={38}
}
OBJECTIVE Growth hormone deficiency in adults with hypopituitarism has previously received little attention. Recent data, however, suggest that GH deflciency might be essential for the long‐term prognosis of these patients. Earlier studies have documented that GH regulates body composition; in this, body composition in adult patients with hypopituitarism including GH deficiency was studied. DESIGN A follow‐up study of patients with hypopituitarism on routine replacement therapy with l‐thyroxine… Expand
Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults *
TLDR
This work has assessed body composition and bone mass in GH deficient hypopituitary adults on conventional replacement therapy and compared them with matched controls. Expand
Growth hormone replacement therapy in adults
TLDR
Observations provide strong evidence that adults with organic GH deficiency should have GH replacement, a principle consistent with the tenet of hormone replacement for hormone deficiency. Expand
Replacement treatment with biosynthetic human growth hormone in growth hormone‐deficient hypopituitary adults *
TLDR
The clinical effects and the effects on body composition of prolonged replacement with biosynthetic human GH in a large number of hypopituitary adults are studied. Expand
The Diagnosis of Adult Growth Hormone Deficiency
Recent clinical studies of growth hormone (GH) treatment in adults suspected of having GH deficiency have demonstrated beneficial effects on body composition, physical fitness, and psychologicalExpand
Diagnosis and management of growth hormone deficiency in adults.
TLDR
Treatment with growth hormone reverses abnormalities in body composition and may reduce cardiovascular risk factors; however, the long-term treatment outcomes regarding mortality, the incidence of cardiovascular disease, bone fractures, tumor development, and recurrence are not known. Expand
Endothelial dysfunction in hypopituitary adults with growth hormone deficiency
TLDR
A noninvasive method is used to assess endothelial function in the brachial arteries of a group of treated hypopituitary adults with GHD, and agroup of healthy age‐and sex‐matched controls. Expand
Growth Hormone (GH) Treatment in GH-Deficient Adults; Therapeutic and Diagnostic Aspects
TLDR
It is concluded that GH-deficiency in adults is associated with a number of subnormal features and GH treatment improves (normalizes) these symptoms and it is believed that GH replacement therapy of aGH-deficient individual should be continued after cessation of linear growth. Expand
Untreated growth hormone deficiency explains premature mortality in patients with hypopituitarism.
  • B. Bengtsson
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 1998
TLDR
There is growing evidence that treatment with growth hormone (GH) can rectify most of the cardiovascular abnormalities associated with GHD, and the reported improved psychosocial well-being in response to GH treatment may also be important in lowering risk in this group of patients. Expand
Growth hormone replacement therapy in adults
(GH) deficiency on conventional hormone replacement therapies is impaired and their cardiovascular mortality is increased. GH-deficient adults suffer from disturbance of fuel metabolism, abnormalExpand
Adult Growth Hormone Deficiency — the Clinical Picture
Lacking or ceased GH secretion from the pituitary gland results in an abnormal metabolic condition where e.g. fasting and stress will be characterised by a relative increase in protein metabolism andExpand
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