Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model.

@article{Takeda2013IncreasedBB,
  title={Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model.},
  author={Shuko Takeda and Naoyuki Sato and Kazuko Ikimura and Hirohito Nishino and Hiromi Rakugi and Ryuichi Morishita},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 8},
  pages={2064-70}
}
Behavioral and psychological problems are often observed in patients with dementia such as that associated with Alzheimer disease, and these noncognitive symptoms place an extremely heavy burden on the family and caregivers. Although it is well know that these symptoms often are triggered by infection of peripheral organs, the underlying mechanisms for these pathological conditions are still unclear. In this study, using an Alzheimer amyloid precursor protein (APP)-transgenic mouse, we analyzed… CONTINUE READING
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