Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals—correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels

@article{Andersson2001IncreasedBB,
  title={Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals—correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels},
  author={L. M. Andersson and Lars Axel Hagberg and Dietmar Fuchs and Bo Svennerholm and Magnus Gissl{\'e}n},
  journal={Journal of NeuroVirology},
  year={2001},
  volume={7},
  pages={542-547}
}
The objective of this study was to assess the frequency of blood-brain barrier (BBB) impairment, as measured by the albumin ratio, in neuro-asymptomatic HIV-1-infected individuals without antiretroviral treatment and the correlation between BBB disruption and intrathecal immune activation and HIV-1 RNA levels. Serum and cerebrospinal fluid (CSF) albumin, neopterin, and HIV-1 RNA levels were analysed in 110 neuro-asymptomatic HIV-1-infected individuals at different stages of disease; 63… CONTINUE READING
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