Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet.

@article{Xu2006IncreasedBL,
  title={Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet.},
  author={Jian-guo Xu and Ana L Mora and John LaVoy and Kenneth L. Brigham and M. Diaz de Rojas},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 4},
  pages={L658-67}
}
The reasons for variable sensitivity among and within species to lung injury and fibrosis caused by bleomycin (BLM) are unknown. Because T helper (Th) 1 and 2 (Th1 and Th2) polarization of CD4+ T lymphocytes is one of the factors that affects the BLM response, we hypothesized that preventing expression of the Th1 transcription factor T-bet would render BLM… CONTINUE READING