Corpus ID: 3506790

Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.

@article{Hassell1980IncreasedBO,
  title={Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.},
  author={J. Hassell and D. Newsome and L. D. De Luca},
  journal={Investigative ophthalmology \& visual science},
  year={1980},
  volume={19 6},
  pages={
          642-7
        }
}
The biosynthesis of corneal epithelial proteins and glycoconjugates and their response to vitamin A were measured in vitamin A-deficient and normal rats. The synthesis of specific high-molecular-weight epithelial glycoconjugates was directly related to the levels of vitamin A administered. Protein synthesis, however, remained unaltered. Since vitamin A is known to reverse the keratinization process, the vitamin A-regulated high-molecular-weight glycoconjugates may play a role in modulating the… Expand
VITAMIN A‐INDUCED ALTERATIONS IN CORNEAL AND CONJUNCTIVAL EPITHELIAL GLYCOPROTEIN BIOSYNTHESIS
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Corneas of normal and vitamin A-deficient rabbits were treated topically with [11, 12-3H] retinol or all-trans retinoic acid and Radiolabeled compounds were extracted from the corneas which co-migrated chromatographically with known retinoid standards. Expand
HETEROGENEITY, POLYDISPERSITY, AND PHYSIOLOGIC ROLE OF CORNEAL PROTEOGLYCANS
TLDR
It is concluded that the molecular size of corneal proteoglycans makes them appropriate as ‘spacers’ between the collagen fibrils, a property important for cornesal transparency. Expand
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Retinoids, cancer, and the skin.
TLDR
The history, chemistry, metabolism, mechanism of action, toxicity, and clinical applications of both the naturally occurring and synthetic retinoids are reviewed. Expand
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