Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.

@article{Dietrich2001IncreasedBO,
  title={Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.},
  author={Christoph G. Dietrich and Dirk Rudi de Waart and Roelof Ottenhoff and Ivo G Schoots and Ronald P. J. Oude Elferink},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 5},
  pages={974-80}
}
MRP2 is an apical transporter expressed in hepatocytes and the epithelial cells of the small intestine and kidney proximal tubule. It extrudes organic anions, conjugated compounds, and some uncharged amphipaths. We studied the transport of an abundant food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro, using an MRP2 transfected epithelial cell line (MDCK II) and intestinal explants from Wistar and MRP2-deficient TR(-) rats in Ussing chambers. In the… CONTINUE READING