Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo.

@article{Sellin2001IncreasedBE,
  title={Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo.},
  author={Joseph H. Sellin and S Radin Umar and Jiaqi Xiao and Andrew P. Morris},
  journal={Cancer research},
  year={2001},
  volume={61 7},
  pages={2899-906}
}
Beta-catenin performs critical roles in development and cellular adhesion. More recently, an oncogenic role has been described. In colon cancer, decreased E-cadherin/beta-catenin association is causally linked to increased beta-catenin-regulated gene expression and increased cellular division. Whether the same pathway is active in native epithelia remains unknown. To address this question, we used the transmissible murine colonic hyperplasia model to measure changes in beta-catenin abundance… CONTINUE READING

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Murine colonic mucosa hyperproliferation. II. PKCb activation and cPKC mediated cellular CFTR over-expression

  • S. Umar, J. Scott, J. Sellin, A. P. Morris
  • Am. J. Physiol.,278:
  • 2000

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