Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.

@article{Casley1997IncreasedBE,
  title={Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.},
  author={William L. Casley and Jacqueline Menzies and Normand Mousseau and Martine Girard and Thomas Moon and Larry W. Whitehouse},
  journal={Pharmacogenetics},
  year={1997},
  volume={7 4},
  pages={
          283-93
        }
}
Susceptibility to acetaminophen-induced hepatotoxicity was found to vary widely in an outbred colony of Swiss Webster mice. Some acetaminophen-treated male mice showed a significant elevation in serum levels of the hepatic enzyme alanine aminotransferase at a normally non-hepatotoxic oral dose. A selective breeding program over 17 generations produced inbred mice which were either susceptible or nonsusceptible to the hepatotoxic effects of acetaminophen. Liver microsomes from the susceptible… CONTINUE READING
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