Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

@inproceedings{Bargiela2015IncreasedAA,
  title={Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model},
  author={Ariadna Bargiela and Estefan{\'i}a Cerro-Herreros and Juan M Fernandez-Costa and Juan Jes{\'u}s V{\'i}lchez and Beatriz Llamus{\'i} and Rub{\'e}n Artero},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced… CONTINUE READING
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