Increased autophagic degradation of mitochondria in Alzheimer disease.

@article{Moreira2007IncreasedAD,
  title={Increased autophagic degradation of mitochondria in Alzheimer disease.},
  author={Paula I Moreira and Sandra Siedlak and Xinglong Wang and Maria Santos and Catarina Resende de Oliveira and Massimo Tabaton and Akihiko Nunomura and Luke I. Szweda and Gjumrakch Aliev and Mark A. Smith and Xiongwei Zhu and George Perry},
  journal={Autophagy},
  year={2007},
  volume={3 6},
  pages={
          614-5
        }
}
Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer disease. Mitochondria are a major source of intracellular reactive oxygen species and are themselves particularly vulnerable to oxidative stress. It has been recently shown that the immunoreactivity of lipoic acid and cytochrome oxidase-1, two mitochondrial markers, is increased in the cytoplasm of pyramidal neurons in Alzheimer disease cases compared with controls… CONTINUE READING
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