Increased augmentation index and systolic stress in type 1 diabetes mellitus.

  title={Increased augmentation index and systolic stress in type 1 diabetes mellitus.},
  author={Ian B. Wilkinson and Helen MacCallum and D F Rooijmans and Gordon D. Murray and John R. Cockcroft and J Mcknight and David J. Webb},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={93 7},
Type 1 diabetes mellitus is associated with endothelial dysfunction and increased arterial stiffness, both of which may contribute to the excess cardiovascular mortality in such patients. Arterial stiffening increases pulse wave velocity and wave reflection, which augments central systolic pressure and stress. Using the non-invasive technique of pulse wave analysis, we investigated aortic augmentation and central pressure in 35 patients with type 1 diabetes and 35 matched controls. Peripheral… CONTINUE READING
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