Increased atrial natriuretic peptide mRNA expression in the kidney of diabetic rats.

@article{Shin1997IncreasedAN,
  title={Increased atrial natriuretic peptide mRNA expression in the kidney of diabetic rats.},
  author={Sookyung Shin and Yong Jun Lee and Ma. Carmen S. Tan and Thomas J.C. Hsieh and Ju- He Tsai},
  journal={Kidney international},
  year={1997},
  volume={51 4},
  pages={
          1100-5
        }
}
To investigate whether renal synthesis of atrial natriuretic peptide (ANP) is influenced in diabetes, we measured renal ANP mRNA levels, urine volume, urinary ANP and sodium excretion rates in streptozotocin (STZ)-induced diabetic rats. By using reverse transcription-polymerase chain reaction (RT-PCR) followed by Southern blot analysis, we found that renal cortical and outer medullary ANP mRNA levels in untreated diabetic rats were markedly increased as early as the second day after the onset… CONTINUE READING
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Increased C-type natriuretic peptide mRNA expression in the kidney of diabetic rats.

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