Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.

  title={Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.},
  author={Roozbeh Aschar-Sobbi and Farzad Izaddoustdar and Adam S Korogyi and Qiongling Wang and Gerrie P. Farman and Fenghua Yang and Wallace Yang and David Dorian and Jeremy A Simpson and Jari Michael Tuomi and Douglas L. Jones and Kumaraswamy Nanthakumar and Brian J Cox and Xander H T Wehrens and P. Dorian and Peter Backx},
  journal={Nature communications},
Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of swimming or treadmill exercise improves heart pump function and reduces heart-rates. Exercise also increases vulnerability to AF in association with inflammation, fibrosis, increased vagal tone, slowed conduction velocity, prolonged cardiomyocyte action potentials and RyR2 phosphorylation (CamKII-dependent S2814) in the… CONTINUE READING
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