Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.

@article{AscharSobbi2015IncreasedAA,
  title={Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.},
  author={Roozbeh Aschar-Sobbi and Farzad Izaddoustdar and Adam S Korogyi and Qiongling Wang and Gerrie P. Farman and Fenghua Yang and Wallace Yang and David Dorian and Jeremy A Simpson and Jari Michael Tuomi and Douglas L. Jones and Kumaraswamy Nanthakumar and Brian J Cox and Xander H T Wehrens and P. Dorian and Peter Backx},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={6018}
}
Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of swimming or treadmill exercise improves heart pump function and reduces heart-rates. Exercise also increases vulnerability to AF in association with inflammation, fibrosis, increased vagal tone, slowed conduction velocity, prolonged cardiomyocyte action potentials and RyR2 phosphorylation (CamKII-dependent S2814) in the… CONTINUE READING
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References

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Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation

  • N Voigt
  • Circulation 129,
  • 2014

Increased risk of atrial fibrillation among elderly Norwegian men with a history of long-term endurance sport practice

  • M Myrstad
  • Scand. J. Med. Sci. Sports 24,
  • 2014

Evidence for an exercise induced increase of TNF-alpha and IL-6 in marathon runners

  • C Bernecker
  • Scand. J. Med. Sci. Sports
  • 2013

a cohort study

  • Andersen, K. et al. Risk of arrhythmias in 52 755 long-distance skiers
  • Eur. Heart J. 34, 3624–3631
  • 2013

demonstration and mechanistic exploration in an animal model

  • Guasch, E. et al. Atrial fibrillation promotion by endurance exercise
  • J. Am. Coll. Cardiol. 62, 68–77
  • 2013

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