Increased atherosclerosis in mice with vascular ATP-binding cassette transporter G1 deficiency--brief report.

OBJECTIVE The objective of this study was to investigate the role of vascular ATP-binding cassette transporter G1 (ABCG1) in atherogenesis without a confounding difference in macrophage ABCG1 expression. ABCG1 is highly expressed in macrophages and endothelial cells. ABCG1 preserves endothelial function by maintaining endothelial NO synthase activity and by… CONTINUE READING