Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk

@article{Mills2007IncreasedAS,
  title={Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk},
  author={Nicholas L. Mills and J J Miller and Atul Anand and Simon D. Robinson and G A Frazer and D. Anderson and L Breen and Ian B. Wilkinson and Carmel M. McEniery and Ken Donaldson and David E. Newby and W. MacNee},
  journal={Thorax},
  year={2007},
  volume={63},
  pages={306 - 311}
}
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with a 2–3-fold increase in the risk of ischaemic heart disease, stroke and sudden death. The mechanisms responsible for this association are not clear and appear to be independent of smoking history. Objective: We test the hypothesis that patients with COPD have increased arterial stiffness and blood pressure in comparison with age and smoking matched controls. Methods: In a prospective case control study, we recruited 102… 

Figures and Tables from this paper

Carotid arterial stiffness in patients with chronic obstructive pulmonary disease.
TLDR
In severe forms of COPD, arterial stiffness seems to be more important than in mild and moderate pulmonary disease, and patients with COPD had increased carotid arterials stiffness.
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
TLDR
The findings suggest that the cardiovascular burden observed in this condition may be mediated through these mechanisms and supports the concept that chronic obstructive pulmonary disease is an independent risk factor for cardiovascular disease.
Arterial stiffness in symptomatic smokers with normal lung function
TLDR
The current investigation shows that the cardiovascular risk occurs in smokers with respiratory symptoms in the absence of bronchial obstruction, and these findings need to be confirmed in larger populations in order to inform the design of intensive preventive programmes.
Determinants of arterial stiffness in COPD
TLDR
Elevated arterial stiffness in patients with COPD can be predicted using age, blood pressure and thoracic aortic calcification, and body mass index, therapy with cholesterol lowering medications and coronary calcification were independent predictors of CVD.
Vascular dysfunction in chronic obstructive pulmonary disease.
TLDR
Increased arterial stiffness may represent the mechanistic link between COPD and the increased risk for cardiovascular disease associated with this condition.
Arterial Stiffness Measured Via Carotid Femoral Pulse Wave Velocity Is Associated With Disease Severity in COPD
TLDR
The results suggest that arterial stiffness is increased in subjects with more severe and advanced COPD than in those with mild to moderate COPD, and air flow limitation and hypoxemia may induce increased arterial stiffened patients.
Arterial stiffness measured by carotid femoral pulse wave velocity is associated with disease severity in chronic obstructive pulmonary disease
TLDR
The results suggest that cf-PWV, a measure of arterial stiffness, is increased in patients with more severe and advanced COPD as compared to those with mild and moderate forms.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL STIFFNESS
TLDR
Early detection of arterial stiffness in COPD patients is warranted to detect cardiovascular comorbidity at the subclinical stage, which would help to prevent overt vascular events in the future.
...
...

References

SHOWING 1-10 OF 61 REFERENCES
Reduced pulmonary function is associated with central arterial stiffness in men.
TLDR
It is suggested that reduced pulmonary function is independently associated with aortic stiffness in men, and negative associations of PWV with lung function measurements were observed within each category of cardiovascular risk factors.
Assessment of arterial stiffness in clinical practice.
TLDR
It will become necessary for physicians both in primary care and hospital practice to understand the importance of arterial stiffness and the techniques available for its clinical assessment, which will be the focus of this review.
Arterial Stiffness, Wave Reflections, and the Risk of Coronary Artery Disease
TLDR
AIx and AP, noninvasively determined manifestations of arterial stiffening and increased wave reflections, are strong, independent risk markers for premature coronary artery disease.
Acute Systemic Inflammation Increases Arterial Stiffness and Decreases Wave Reflections in Healthy Individuals
TLDR
This is the first study to show through a cause-and-effect relationship that acute systemic inflammation leads to deterioration of large-artery stiffness and to a decrease in wave reflections, given the importance of aortic stiffness for cardiovascular function and risk.
C-reactive protein levels and clinically important predictive outcomes in stable COPD patients
TLDR
C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance and the strongest negative association with CRP levels is found with Pa,O2 and 6MWD.
Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients
TLDR
This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
Impact of Smoking and Smoking Cessation on Arterial Stiffness and Aortic Wave Reflection in Hypertension
TLDR
In ex-smokers, duration of smoking cessation had a significant linear relationship with improvement in pulse wave velocity, AIx, and TR, with arterial stiffness parameters returning to nonsignificant levels after a decade ofsmoking cessation.
Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality.
  • D. Sin, S. Man
  • Medicine
    Proceedings of the American Thoracic Society
  • 2005
TLDR
Overall, when the lowest quintile of lung function, as measured by FEV1 is compared with the highest quintile, the risk of cardiovascular mortality increases by approximately 75% in both men and women.
Augmentation of central arterial pressure in mild primary hyperparathyroidism.
TLDR
Data indicate that subjects with mild PHPT have increased arterial stiffness, as evidenced by higher augmentation of central aortic pressures, which may arise from a combination of structural and functional vascular changes due to hypercalcemia and/or metabolic abnormalities.
...
...