Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease.

  title={Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease.},
  author={Scott J. Horowitz and David G. Binion and Victoria M Nelson and Yasmin Kanaa and Pooria Javadi and Zelmira Lazarova and Christopher Andrekopoulos and Balaraman Kalyanaraman and Mary Francis Otterson and Parvaneh Rafiee},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={292 5},
Nitric oxide (.NO) generation from conversion of l-arginine to citrulline by nitric oxide synthase isoforms plays a critical role in vascular homeostasis. Loss of .NO is linked to vascular pathophysiology and is decreased in chronically inflamed gut blood vessels in inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). Mechanisms underlying decreased .NO production in IBD gut microvessels are not fully characterized. Loss of .NO generation may result from increased arginase… CONTINUE READING


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