Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia.

@article{Courtney1999IncreasedAP,
  title={Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia.},
  author={Phillip A Courtney and Alistair D. Crockard and K. Williamson and Alexandra Elizabeth Irvine and Rebekah J. Kennedy and Aubrey L. Bell},
  journal={Annals of the rheumatic diseases},
  year={1999},
  volume={58 5},
  pages={309-14}
}
OBJECTIVE To quantify the percentage of apoptotic peripheral blood neutrophils in systemic lupus erythematosus (SLE) and to determine the relations with disease activity and neutropenia. METHODS Neutrophil apoptosis in SLE patients (n =50) was assessed by flow cytometry using annexin V binding and fluorescent labelled anti-fas. Rheumatoid arthritis (RA, n =20) and inflammatory bowel disease patients (IBD, n =20) were studied as disease controls. RESULTS The percentage of apoptotic… CONTINUE READING