Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation.

@article{Lin2000IncreasedAO,
  title={Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation.},
  author={M T Lin and L. H. Tseng and Haydar A. Frangoul and Theodore A Gooley and Ji Pei and A A Barsoukov and Yoshiki Akatsuka and John A Hansen},
  journal={Blood},
  year={2000},
  volume={95 12},
  pages={3832-9}
}
Lymphopenia and immune deficiency are significant problems following allogeneic hematopoietic cell transplantation (HCT). It is largely assumed that delayed immune reconstruction is due to a profound decrease in thymus-dependent lymphopoiesis, especially in older patients, but apoptosis is also known to play a significant role in lymphocyte homeostasis. Peripheral T cells from patients who received HCT were studied for evidence of increased cell death. Spontaneous apoptosis was measured in CD3… CONTINUE READING