Increased apoptosis and secretion of tryptase by mast cells in infantile haemangioma treated with propranolol.

@article{Steel2014IncreasedAA,
  title={Increased apoptosis and secretion of tryptase by mast cells in infantile haemangioma treated with propranolol.},
  author={Ryan W J Steel and Darren Day},
  journal={Pathology},
  year={2014},
  volume={46 6},
  pages={496-500}
}
Propranolol is increasingly used to treat problematic infantile haemangioma (IH), although its molecular mechanisms remain unclear. A key feature of propranolol therapy is the decreased deposition of fibrofatty residuum compared with spontaneously involuting IH. This study investigated the molecular consequences of propranolol treatment for IH in vivo.Immunohistochemical and terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining was performed on five age matched patients… CONTINUE READING