Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism.

@article{Vuong2010IncreasedAB,
  title={Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF2 receptor antagonism.},
  author={Shawn M Vuong and Harvey A Oliver and Jamie L. Scholl and Kathryn M. Oliver and Gina L. Forster},
  journal={Behavioural brain research},
  year={2010},
  volume={208 1},
  pages={278-81}
}
Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF(2) receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN). In the current study, amphetamine (2.5 mg/kg, i.p., 14 days) pre-treated rats spent less time in open arms of the elevated plus maze compared saline pre-treated rats at both 24h or 2 weeks of withdrawal, and CRF(2) receptor antagonism (ASV-30; 2 microg/0.5 microl) within the dRN reversed the effects of… CONTINUE READING