Increased anxiety in mice lacking vitamin D receptor gene

@article{Kalueff2004IncreasedAI,
  title={Increased anxiety in mice lacking vitamin D receptor gene},
  author={Allan V. Kalueff and Yan-Ru Lou and Ilkka Laaksi and Pentti Tuohimaa},
  journal={NeuroReport},
  year={2004},
  volume={15},
  pages={1271-1274}
}
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various behavioural disorders. To examine this problem, we studied whether genetic ablation of vitamin D receptors in mice may be associated with altered emotional behaviours. Here we show that the receptor-deficient mice demonstrate increased anxiety-like behaviours when subjected to a battery of behavioural… 
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TLDR
The association of the nuclear receptor signalling pathways with several diseases suggests that they are less likely to be responsible for the unique features of each disease but are involved in aspects common to the disorders, as has been proposed for genes such as DISC1.
Vitamin D, cognitive function, and mental health
Abstract: Although it has long thought to be primarily involved in calcium regulation and bone metabolism, vitamin D is now believed to play an important role in the process of neural development,…
Thalamic calcification in vitamin D receptor knockout mice
TLDR
It is reported that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies, which is consistent with clinical findings showing brain calcification in patients with vitamin D deficiency.
Vitamin D deficiency impairs neurobehavioral development in male mice
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References

SHOWING 1-10 OF 18 REFERENCES
Behavioral correlates of vitamin D deficiency
Evidence of functional vitamin D receptors in rat hippocampus
Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia.
  • Y. Li, A. Pirro, +4 authors M. Demay
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
A mouse model of VDDR II is generated by targeted ablation of the second zinc finger of the VDR DNA-binding domain and homozygous mice are phenotypically normal at birth and demonstrate normal survival at least until 6 months, compared to animals made vitamin D deficient by dietary means.
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
TLDR
It is reported here that in VDR null mutant mice, no defects in development and growth were observed before weaning, irrespective of reduced expression of vitamin D target genes, which establishes a critical role for VDR in growth, bone formation and female reproduction in the post-weaning stage.
New clues about vitamin D functions in the nervous system
Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.
TLDR
It is indicated that vitamin D is essential for full gonadal function in both sexes and direct regulation of the expression of the aromatase gene should not be neglected.
Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder.
TLDR
Vitamin D status improved in both groups and improvement in 25-OH D was significantly associated with improvement in depression scale scores, suggesting that vitamin D may be an important treatment for SAD.
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors.
TLDR
The present study finds that each muscle fiber was small and variable in size in hindlimb skeletal muscle from VDR -/- mice, although overall myocyte differentiation occurred normally, suggesting that VDR plays a physiological role in skeletal muscle development, participating in temporally strict down-regulation of myoregulatory transcription factors.
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
High versus low reactivity to a novel environment: behavioural, pharmacological and neurochemical assessments
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