Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

@inproceedings{Issler2013IncreasedAI,
  title={Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas},
  author={Orna Issler and Roderick N Carter and Evan D. Paul and Paul A. T. Kelly and Henry J. Olverman and Adi Neufeld-Cohen and Yael Kuperman and Christopher A Lowry and Jonathan R Seckl and Alon Chen and Pauline M. Jamieson},
  booktitle={Biology of Mood & Anxiety Disorders},
  year={2013}
}
Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulate serotonergic neuronal activity and have been demonstrated to mediate behavioural consequences of stress. Here, we describe behavioural and serotonergic responses consistent with maladaptive recovery from stressful challenge in CRFR2-null mice. CRFR2-null mice showed similar anxiety… CONTINUE READING