Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder.

@article{Grillon2008IncreasedAD,
  title={Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder.},
  author={Christian Grillon and Shmuel Lissek and Stephanie J. Rabin and Dana J McDowell and Sharone Dvir and Daniel S. Pine},
  journal={The American journal of psychiatry},
  year={2008},
  volume={165 7},
  pages={898-904}
}
OBJECTIVE Predictability is a fundamental modulator of anxiety in that the ability to predict aversive events mitigates anxious responses. In panic disorder, persistent symptoms of anxiety are caused by anticipation of the next uncued (unpredictable) panic attack. The authors tested the hypothesis that elevated anxious reactivity, specifically toward unpredictable aversive events, is a psychophysiological correlate of panic disorder. METHOD Participants were exposed to one condition in which… CONTINUE READING

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