Increased antioxidant enzyme activity in amyloid beta protein-resistant cells.

  title={Increased antioxidant enzyme activity in amyloid beta protein-resistant cells.},
  author={Yutaka Sagara and Richard Dargusch and F. George Klier and David Schubert and Christian Behl},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={16 2},
Clones of the rat pheochromocytoma cell line PC12 were selected for their resistance to amyloid beta protein (A beta). These A beta-resistant cells also survive higher concentrations of exogenously applied peroxides than the parent cells. A beta triggers intracellular H2O2 accumulation in the parent PC12 cells but not in the A beta-resistant cells. The absence of H2O2 accumulation in A beta-resistant cells is not attributable to differences in A beta binding to the cell surface. However, the… CONTINUE READING


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