Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown

@article{Nag2005IncreasedAE,
  title={Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown},
  author={Sukriti Nag and Tripti Papneja and Roopa Venugopalan and Duncan J Stewart},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={1189-1198}
}
Normal intracerebral and pial vessels show constitutive expression of angiopoietin (Ang) 1 in endothelium while weak Ang2 immunoreactivity is present in occasional vessels. In the early phase postinjury, blood–brain barrier (BBB) breakdown at the lesion site is associated with decreased endothelial Ang1 and increased Ang2 expression, raising the possibility that Ang2 may have a role in early BBB breakdown. In order to determine whether Ang2 can cause BBB breakdown, the effect of recombinant… CONTINUE READING