Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF.

@article{Nillesen2007IncreasedAA,
  title={Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF.},
  author={Suzan T M Nillesen and Paul J. Geutjes and Ronnie G P Wismans and Joost Schalkwijk and Willeke F Daamen and Toin H van Kuppevelt},
  journal={Biomaterials},
  year={2007},
  volume={28 6},
  pages={1123-31}
}
An important issue in tissue engineering is the vascularisation of the implanted construct, which often takes several weeks. In vivo, the growth factors VEGF and FGF2 show a combined effect on both angiogenesis and maturation of blood vessels. Therefore, we hypothesise that the addition of these growth factors to an acellular construct increases blood vessel formation and maturation. To systematically evaluate the contribution of each scaffold component with respect to tissue response and in… CONTINUE READING

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