Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.

@article{Lawson2005IncreasedAP,
  title={Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.},
  author={William E. Lawson and Vasiliy V. Polosukhin and Georgios T Stathopoulos and Ornella Zoia and Wei Han and Kirk B. Lane and Bo Li and Edwin F. Donnelly and George E Holburn and Kenneth G Lewis and Robert D. Collins and William M. Hull and Stephan W. Glasser and Jeffrey A. Whitsett and Timothy S. Blackwell},
  journal={The American journal of pathology},
  year={2005},
  volume={167 5},
  pages={1267-77}
}
Recent reports have linked mutations in the surfactant protein C gene (SFTPC) to familial forms of pulmonary fibrosis, but it is uncertain whether deficiency of mature SP-C contributes to disease pathogenesis. In this study, we evaluated bleomycin-induced lung fibrosis in mice with genetic deletion of SFTPC. Compared with wild-type (SFTPC+/+) controls, mice lacking surfactant protein C (SFTPC-/-) had greater lung neutrophil influx at 1 week after intratracheal bleomycin, greater weight loss… CONTINUE READING

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