Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice.

@article{LangeAsschenfeldt2002IncreasedAP,
  title={Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice.},
  author={Bernhard Lange-Asschenfeldt and Wolfgang Weninger and Paula Velasco and Themis R Kyriakides and Ulrich H von Andrian and Paul Bornstein and Michael Detmar},
  journal={Blood},
  year={2002},
  volume={99 2},
  pages={538-45}
}
Angiogenesis and enhanced microvascular permeability are hallmarks of a large number of inflammatory diseases. Although up-regulation of proangiogenic factors such as vascular endothelial growth factor and interleukin-8 have been previously reported in inflamed tissue, the biologic role of endogenous inhibitors of angiogenesis in inflammation has remained unclear. To investigate the biologic role of the potent angiogenesis inhibitor thrombospondin-2 (TSP-2) in the control of cutaneous… CONTINUE READING

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