Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy.

@article{Gaillard1993IncreasedAH,
  title={Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy.},
  author={Jean Philippe Gaillard and R{\'e}gis Bataille and Herv{\'e} Brailly and Christian Zuber and Kiyoshi Yasukawa and Michel Attal and Naomi Maruo and Tetsuya Taga and Tadamitsu Kishimoto and Bernard Klein},
  journal={European journal of immunology},
  year={1993},
  volume={23 4},
  pages={820-4}
}
Soluble human interleukin-6 receptor (sIL-6R) was measured in the serum of 30 healthy individuals, 32 individuals with monoclonal gammopathy of undetermined significance (MGUS), 20 patients with early multiple myeloma (MM) and 54 patients with overt MM. The serum activity recognized by an immunoradiometric assay was determined to be sIL-6R, because of its binding capacity to IL-6 and its molecular mass of 55 kDa. All sera of healthy individuals contained sIL-6R (mean value: 89 ng/ml, range 17… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…