Increased and correlated expression of connective tissue growth factor and transforming growth factor beta 1 in surgically removed periodontal tissues with chronic periodontitis.

@article{Mize2015IncreasedAC,
  title={Increased and correlated expression of connective tissue growth factor and transforming growth factor beta 1 in surgically removed periodontal tissues with chronic periodontitis.},
  author={Travis Mize and Kamala P. Sundararaj and Renata Serricchio Leite and Yu Xia Huang},
  journal={Journal of periodontal research},
  year={2015},
  volume={50 3},
  pages={
          315-9
        }
}
BACKGROUND AND OBJECTIVE Both gingival tissue destruction and regeneration are associated with chronic periodontitis, although the former overwhelms the latter. Studies have shown that transforming growth factor beta 1 (TGF-β1), a growth factor largely involved in tissue regeneration and remodeling, is upregulated in chronic periodontitis. However, the gingival expression of connective tissue growth factor (CTGF or CCN2), a TGF-β1-upregulated gene, in patients with periodontitis remains… CONTINUE READING
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