Increased analgesic potency of mu agonists after continuous naloxone infusion in rats.

@article{Paronis1991IncreasedAP,
  title={Increased analgesic potency of mu agonists after continuous naloxone infusion in rats.},
  author={Carol A. Paronis and Stephen G. Holtzman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={259 2},
  pages={582-9}
}
Chronic opioid antagonist administration increases opioid binding sites and potentiates behavioral responses to morphine. The present study was designed to examine in rats the temporal and dosage parameters of naloxone-induced potentiation of morphine analgesia and the effect of continuous infusion of naloxone on the analgesic potency of other mu agonists. Cumulative dose-response curves were generated in a tail-flick procedure for each drug tested. Naloxone-filled osmotic pumps were then… CONTINUE READING
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…